Conformers:
ABBIImiBZICOPNSYNN
Click the Summary/Torsions/Similar/... tabs for more details.
Human topoisomerase IIalpha in complex with DNA and etoposide
Click a row in table or a step in viewer for analysis of results. Click column headers to sort data.
Steps with non-standard or missing atoms have not been assigned, description of conformers is defined in the table.
Results of the assignment of 36 detected steps in 1 model(s), can be also downloaded as csv or json file. Average confal 0, percentile 0.
Click a row in table or a step in viewer for analysis of results. Click column headers to sort data.
Define restraints for steps within Å cartesian RMSD, global sigma scaling factor or use per step sigma scaling.
| step number | Step name | CANA | NtC | confal | rmsd |
|---|---|---|---|---|---|
| 01 | 5gwk_C_DA1_DG2 | BB2 | BB07 | 69 | 0.28 |
| 02 | 5gwk_C_DG2_DC3 | B12 | BB04 | 88 | 0.14 |
| 03 | 5gwk_C_DC3_DC4 | NAN | NANT | 0 | 0.55 |
| 04 | 5gwk_C_DC4_DG5 | NAN | NANT | 0 | 0.60 |
| 05 | 5gwk_C_DG5_DA6 | B12 | BB04 | 61 | 0.28 |
| 06 | 5gwk_C_DA6_DG7 | B-A | BA10 | 75 | 0.20 |
| 07 | 5gwk_C_DG7_DC8 | AAA | AA00 | 67 | 0.26 |
| 08 | 5gwk_D_DT9_DG10 | A-B | AB01 | 61 | 0.18 |
| 09 | 5gwk_D_DG10_DC11 | B-A | BA01 | 52 | 0.19 |
| 10 | 5gwk_D_DC11_DA12 | AAA | AA02 | 89 | 0.17 |
| 11 | 5gwk_D_DA12_DG13 | NAN | NANT | 0 | 0.36 |
| 12 | 5gwk_D_DG13_DC14 | AAA | AA00 | 61 | 0.32 |
| 13 | 5gwk_D_DC14_DT15 | A-B | AB05 | 70 | 0.31 |
| 14 | 5gwk_D_DT15_DC16 | NAN | NANT | 0 | 0.73 |
| 15 | 5gwk_D_DC16_DG17 | NAN | NANT | 0 | 0.67 |
| 16 | 5gwk_D_DG17_DG18 | BBB | BB00 | 40 | 0.28 |
| 17 | 5gwk_D_DG18_DC19 | B-A | BA01 | 19 | 0.18 |
| 18 | 5gwk_D_DC19_DT20 | NAN | NANT | 0 | 0.42 |
| 19 | 5gwk_E_DA1_DG2 | BB2 | BB07 | 70 | 0.32 |
| 20 | 5gwk_E_DG2_DC3 | B12 | BB04 | 87 | 0.17 |
| 21 | 5gwk_E_DC3_DC4 | NAN | NANT | 0 | 0.52 |
| 22 | 5gwk_E_DC4_DG5 | NAN | NANT | 0 | 0.57 |
| 23 | 5gwk_E_DG5_DA6 | B12 | BB04 | 61 | 0.28 |
| 24 | 5gwk_E_DA6_DG7 | B-A | BA10 | 77 | 0.19 |
| 25 | 5gwk_E_DG7_DC8 | AAA | AA00 | 66 | 0.26 |
| 26 | 5gwk_F_DT9_DG10 | A-B | AB01 | 61 | 0.18 |
| 27 | 5gwk_F_DG10_DC11 | B-A | BA01 | 50 | 0.20 |
| 28 | 5gwk_F_DC11_DA12 | AAA | AA02 | 83 | 0.22 |
| 29 | 5gwk_F_DA12_DG13 | NAN | NANT | 0 | 0.38 |
| 30 | 5gwk_F_DG13_DC14 | AAA | AA00 | 58 | 0.32 |
| 31 | 5gwk_F_DC14_DT15 | A-B | AB05 | 71 | 0.31 |
| 32 | 5gwk_F_DT15_DC16 | NAN | NANT | 0 | 0.75 |
| 33 | 5gwk_F_DC16_DG17 | NAN | NANT | 0 | 0.65 |
| 34 | 5gwk_F_DG17_DG18 | BBB | BB00 | 39 | 0.28 |
| 35 | 5gwk_F_DG18_DC19 | B-A | BA01 | 18 | 0.18 |
| 36 | 5gwk_F_DC19_DT20 | NAN | NANT | 0 | 0.42 |
Steps with non-standard or missing atoms have not been assigned, description of conformers is defined in the table.
|
step: Table of conformers |
| δ1 | ε1 | ζ1 | α2 | β2 | γ2 | δ2 | χ1 | χ2 | μ | NN | CC | |
| step_torsions | ||||||||||||
| ntC_average | ||||||||||||
| Δ torsions | ||||||||||||
| torsion scores |
| comments | step confal = NaN cartesian RMSD = NaN Å pseudorotation: NA details: NA |
Similarity of step to class averages
Download
Results as csv or json file.Best NtC fitted to input structure.
Restraints
Restraints file for REFMAC (steps with RMSD <= 0.5Å)Commands file for MMB (steps with RMSD <= 0.5Å)
Restraints file for Phenix (steps with RMSD <= 0.5Å) [?]
Definitions
Average parameters (csv), esd values (csv), and Cartesian coordinates of conformers.Download the papers
Description of DNATCO server:Černý et al., Nucleic Acids Research, 44, W284 (2016).
Definition of conformers:
Schneider et al., Acta Cryst D, 74, 52-64 (2018).
Example of application:
Schneider et al., Genes, 8(10), 278, (2017).
Browse conformers
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